I've encountered the issue with multiple quests. Unfortunately the ordering theory Will mentioned hasn't fixed the issue for me. Here's a list of the current quests I have that are affected by this:
Fine Cutlass Upgrade: Pirate Lore
Bloodletter Upgrade: Stolen Daggers
Grand Pistol Upgrade...
I'm always slightly amused at how half of the people farming loot from General Darkhart crash whenever the fireworks start. Thankfully, I've only experienced the screen freezing for ~4 seconds.