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I second this.It's beyond me how really high graphic settings could ever boost framerate or crash resistance. Personally, I'd just say have vsync on, graphics on custom>low (and everything unchecked), and fancy loading screen off.
In addition, I would recommend playing in windowed mode, it seems to have helped me.
You'll probably have to do a little experimentation of your own, too. For example, people often report that crashes can be reduced by turning off audio and disabling the fancy loading screen, but neither of those had any affect on my crash rate (I would recommend that you try them anyway just to see, since it does seem to have helped some people). Just seems to be a little different for everyone.